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Winnie’s approach using the double-injection technique required more time to perform the block compared with Winnie’s single-injection technique and the parasacral method

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Hyperthermia does not respond to typical antipyretics since there are no pyrogenic molecules ( The Material Basis of Fever Pyrogenic Cytokines In 1948, Beeson obtained a substance from the granulocytes of the sterile peritoneal exudate of rabbits, which would raise the body temperature of normal rabbits after injection (Sajadi, 2015)